Police have increased their stop and search powers in Whalley Range and other areas as well as stepping up patrols over fears of an outbreak of violence.
The enhanced powers will be in use until 6am tomorrow.
They cover Hulme, Moss Side and Whalley Range.
The powers were implemented after a shooting in Moss Side which left a 16-years-old in hospital.
The temporary additional powers allow police to stop and search people in the areas in defined areas.
A spokesman for Greater Manchester Police said: "We can also disperse anyone from the area we believe may cause harm or distress to others.
"We understand the use of these powers can cause concern and can seem excessive.
"We use these powers when we have information people may have weapons in the area, or there is information that there could be violence.
"Our priority is to keep you safe. We’re using these powers to prevent violence involving weapons.
"You will see more officers patrolling these areas over the course of this weekend.
"If you have information about weapons or suspicious activity, get in touch. We can be contacted by Live Chat on our website gmp.police.uk.
"Alternatively, call the Crimestoppers charity on 0800 555 111. They will not ask for your name or trace your call."
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